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RHOG Generas homolog family member G This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011] |
rhog Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term rhog in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
RHOG Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for RHOG from the Pathway Commons Protein-Protein Interactions dataset. |
RHOG Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the RHOG gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
RHOG GTPase cycle Gene Setproteins participating in the RHOG GTPase cycle pathway from the Reactome Pathways 2024 dataset. |