Harmonizome 3.0

short stature homeobox 2

This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term shox2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the Shox2 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SHOX2 from the Pathway Commons Protein-Protein Interactions dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Shox2 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SHOX2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.