Harmonizome 3.0

synaptosomal-associated protein, 23kDa

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term snap23 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SNAP23 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SNAP23 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the SNARE complex (Stx4, Vamp8, Snap23) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX4, SNAP23, VAMP1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX11, VAMP2, SNAP23) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX4, SNAP23, VAMP2) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (Stx4, Vamp2, Snap23) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX6, SNAP23) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX4, VAMP8, VAMP3, SNAP23) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX2, SNAP23) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (SNAP23, STX1A) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX4, SNAP23) protein complex from the CORUM Protein Complexes dataset.