Harmonizome 3.0

syntaxin 4

Enables sphingomyelin phosphodiesterase activator activity. Involved in several processes, including cornified envelope assembly; positive regulation of immune effector process; and positive regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lamellipodium. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse. Implicated in autosomal recessive nonsyndromic deafness. [provided by Alliance of Genome Resources, Mar 2025]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stx4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for STX4 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the STX4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the STX4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the SNARE complex (Stx4, Vamp8, Snap23) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (Stx4, Stx6, Stx7, Vamp3, Vamp7, Vamp8, Vti1b) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX4, SNAP23, VAMP1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX4, VAMP1, VAMP7) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX4, SNAP23, VAMP2) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (Stx4, Vamp2, Snap23) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX4, VAMP8, VAMP3, SNAP23) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX4, SNAP23) protein complex from the CORUM Protein Complexes dataset.