Harmonizome 3.0

poliovirus receptor-related 1 (herpesvirus entry mediator C)

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]

poliovirus receptor-related 2 (herpesvirus entry mediator B)

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Human herpesvirus 8, susceptibility to

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Saimiriine herpesvirus 2 (strain 11) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Saimiriine herpesvirus 2 (strain 488) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 1 (strain Patton) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 1 (strain 17) from the Virus MINT Protein-Virus Interactions dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term herpesvirus in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From HPO Gene-Disease Associations

genes associated with the susceptibility to herpesvirus phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

From OMIM Gene-Disease Associations

genes associated with the {human herpesvirus 8, susceptibility to} phenotype from the curated OMIM Gene-Disease Associations dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 1 from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 6 from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Human herpesvirus 8 from the Virus MINT Protein-Virus Interactions dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Infection By Human Herpesvirus in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Human Herpesvirus 8 Infection in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From KEGG Pathways 2026

proteins participating in the Virion - Herpesvirus pathway from the KEGG Pathways 2026 dataset.

From KEGG Pathways 2026

proteins participating in the Kaposi sarcoma-associated herpesvirus infection pathway from the KEGG Pathways 2026 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term strain in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Sendai virus (strain Fushimi) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Fowl adenovirus 1 (strain CELO / Phelps) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Cottontail rabbit papillomavirus (strain Kansas) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Epstein-Barr virus (strain GD1) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Epstein-Barr virus (strain B95-8) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Murine polyomavirus (strain 3) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Rous sarcoma virus (strain Schmidt-Ruppin A) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Influenza A virus (strain A/Puerto Rico/8/34 H1N1) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Poliovirus type 1 (strain Sabin) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Influenza A virus (strain A/Aichi/2/1968 H3N2) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Hepatitis E virus (strain Burma) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Hepatitis E virus (strain Mexico) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Vaccinia virus (strain Copenhagen) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Avian sarcoma virus (strain PR2257) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Vaccinia virus (strain Western Reserve / WR) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Vaccinia virus (strain L-IVP) from the Virus MINT Protein-Virus Interactions dataset.

From Virus MINT Protein-Virus Interactions

interacting proteins for the virus Simian virus 5 (strain W3) from the Virus MINT Protein-Virus Interactions dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global radial strain phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global circumferential strain (MTAG) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global radial strain (MTAG) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global longitudinal strain (MTAG) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global circumferential strain phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From GWAS Catalog SNP-Phenotype Associations 2025

genes associated with the Left ventricular global longitudinal strain phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the COMMENSAL BACTERIAL STRAIN FORMULATION VE800 drug from theDGIdb Drug Targets 2026 dataset.