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TADA3 Genetranscriptional adaptor 3 DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] |
TADA3 Gene SetFrom NURSA Protein-Protein Interactions interacting proteins for TADA3 from the NURSA Protein-Protein Interactions dataset. |
TADA3 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for TADA3 from the Pathway Commons Protein-Protein Interactions dataset. |
TADA3 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the TADA3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |