Harmonizome 3.0

transducin-like enhancer of split 3

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tle3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for TLE3 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the TLE3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the tle3-aes complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the Tle3-Aes complex protein complex from the CORUM Protein Complexes dataset.

From GO Cellular Component Annotations 2015

proteins localized to the tle3-aes complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.