UHRF1

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Results for "UHRF1": 1 gene, 7 gene sets

Name
UHRF1 Gene ubiquitin-like with PHD and ring finger domains 1 This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
uhrf1 Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term uhrf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
UHRF1 Gene Set From Pathway Commons Protein-Protein Interactions interacting proteins for UHRF1 from the Pathway Commons Protein-Protein Interactions dataset.
UHRF1 Gene Set From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the UHRF1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
UHRF1 Gene Set From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the UHRF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
UHRF1-binding protein 1-like Gene Set From InterPro Predicted Protein Domain Annotations proteins predicted to have the UHRF1-binding protein 1-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.
UHRF1 (UHRF2) Gene Set From NURSA Protein Complexes proteins in the UHRF1 (UHRF2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.
BL2555 (UHRF1) Gene Set From NURSA Protein Complexes proteins in the BL2555 (UHRF1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.