Harmonizome 3.0

cullin-associated and neddylation-dissociated 2 (putative)

Predicted to enable TBP-class protein binding activity. Predicted to be involved in SCF complex assembly; positive regulation of DNA-templated transcription; and protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Mar 2025]

cullin-associated and neddylation-dissociated 1

This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

From MPO Gene-Phenotype Associations

gene mutations causing the dissociated hepatocytes phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

From MGI Mouse Phenotype Associations 2023

gene mutations causing the dissociated hepatocytes phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores

genes co-occuring with the disease dissociated nystagmus in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dissociated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Dissociated Nystagmus in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores 2025

genes co-occuring with the disease Dissociated nystagmus in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the NUCKS1-24931609-HEPATOCYTES-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hepatocytes in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the PPARA_agonist activation_GSE17250_475_mouse_Isolated hepatocytes gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the PPARA_agonist activation_GSE17251_474_human_Isolated hepatocytes gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GWASdb SNP-Phenotype Associations

genes associated with the lipid accumulation in hepatocytes phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

From HPO Gene-Disease Associations

genes associated with the lipid accumulation in hepatocytes phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term hepatocytes in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Lipid Accumulation In Hepatocytes in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

From ChEA Transcription Factor Targets 2022

target genes of the NUCKS1-24931609-HEPATOCYTES-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the E2F1-26619117-HEPATOCYTES-MOUSE-LIVER transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From WikiPathways Pathways 2024

proteins participating in the Fatty acids and lipoproteins transport in hepatocytes pathway from the WikiPathways Pathways 2024 dataset.

From WikiPathways Pathways 2024

proteins participating in the Cholesterol biosynthesis pathway in hepatocytes pathway from the WikiPathways Pathways 2024 dataset.