Harmonizome 3.0

male germ cell-associated kinase

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. Mutations in this gene have been associated with ciliary defects resulting in retinitis pigmentosa 62. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mak in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAK from the Pathway Commons Protein-Protein Interactions dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase MAK from the Kinase Library Serine Threonine Kinome Atlas dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the MAK gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From NURSA Protein Complexes

proteins in the SC-100432 (MAK) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the MAK-related retinopathy phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.