Name

PPOX Gene

protoporphyrinogen oxidase

This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

ppox Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ppox in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PPOX Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PPOX from the Pathway Commons Protein-Protein Interactions dataset.

PPOX Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the PPOX gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.