Harmonizome 3.0

eukaryotic translation initiation factor 2 alpha kinase 4

This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]

GCN1 activator of EIF2AK4

Enables several functions, including protein kinase regulator activity; stalled ribosome sensor activity; and ubiquitin-protein transferase regulator activity. Involved in protein-RNA covalent cross-linking repair. Located in cytosol. Is active in cytosolic ribosome. [provided by Alliance of Genome Resources, Mar 2025]

From NURSA Protein Complexes

proteins in the BL2617 (EIF2AK4) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From KEA Substrates of Kinases

substrates of the kinase EIF2AK4 from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for EIF2AK4 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase EIF2AK4 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the EIF2AK4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Reactome Pathways 2024

proteins participating in the Response of EIF2AK4 (GCN2) to amino acid deficiency pathway from the Reactome Pathways 2024 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the EIF2AK4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.