Harmonizome 3.0

transformation/transcription domain-associated protein

This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

From NURSA Protein Complexes

proteins in the BL4808 (TRRAP) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TRRAP-BAF53-HAT complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the GCN5-TRRAP histone acetyltransferase complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term trrap in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase TRRAP from the curated KEA Substrates of Kinases dataset.

From NURSA Protein-Protein Interactions

interacting proteins for TRRAP from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for TRRAP from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the TRRAP gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the TRRAP-related neurodevelopmental disorder phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the TRRAP gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.