Harmonizome 3.0

CD8a molecule

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd8a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for CD8A from the MSigDB Cancer Gene Co-expression Modules dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CD8A from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CD8A gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CORUM Protein Complexes

proteins in the CD8A-LCK complex protein complex from the CORUM Protein Complexes dataset.

From CellMarker Gene-Cell Type Associations

genes associated with the CD8a+ dendritic cell_Bone marrow_Mouse cell type from the CellMarker Gene-Cell Type Associations dataset.