Harmonizome 3.0

E2F transcription factor 4, p107/p130-binding

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the E2F4-17652178-JURKAT-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets 2022

target genes of the E2F4-17652178-JURKAT-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets

target genes of the E2F4 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From CORUM Protein Complexes

proteins in the pRb2/p130-multimolecular complex (RB2, E2F4, HDAC1, SUV39H1, P300) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RB1(hypophosphorylated)-E2F4 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the E2F4-p130 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the pRb2/p130-multimolecular complex (DNMT1, E2F4, SuV39H1, HDAC1, RBL2) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD3/4-E2F4/5-p107-DP1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the E2F4-p107-cyclinA complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD3-E2F4/5-p107-DP1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the E2F4-p107-cyclinE complex protein complex from the CORUM Protein Complexes dataset.

From ENCODE Transcription Factor Targets

target genes of the E2F4 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transcription factor E2F4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From JASPAR Predicted Transcription Factor Targets

target genes of the E2F4 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

From NURSA Protein Complexes

proteins in the SC-866 (E2F4) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL6523 (E2F4) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein-Protein Interactions

interacting proteins for E2F4 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for E2F4 from the Pathway Commons Protein-Protein Interactions dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the E2F4 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the E2F4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.