Harmonizome 3.0

E2F transcription factor 5, p130-binding

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for E2F5 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the E2F5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the E2f5-Rbl2-Hdac1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the pRb2/p130-multimolecular complex (DNMT1, E2F5, SuV39H1, HDAC1, RBL2) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the E2F5-RB2-DP1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300) protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transcription factor E2F5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC4141782-pone.0105522.s006.xls-E2F5-Unnamed_1_E2F5 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.