Harmonizome 3.0

hepatocyte growth factor (hepapoietin A; scatter factor)

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hgf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the HGF ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for HGF from the Pathway Commons Protein-Protein Interactions dataset.

From CORUM Protein Complexes

proteins in the HGF-Met complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MET-CIN85-SH3GL3-CBL complex, HGF stimulated protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, HGF/MSP receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores

proteins co-occuring with the tissue hgf cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue HGF cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the ANTI-HGF MONOCLONAL ANTIBODY TAK-701 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the VEGF/HGF-TARGETING DARPIN MP0250 drug from theDGIdb Drug Targets 2026 dataset.