Harmonizome 3.0

hepatocyte growth factor-regulated tyrosine kinase substrate

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

From DrugBank Drug Targets

interacting proteins for the HGS-TR2J drug from the curated DrugBank Drug Targets dataset.

From DGIdb Drug Targets 2026

interacting proteins for the HGS-TR2J drug from theDGIdb Drug Targets 2026 dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (HGS, SNAP25, STX13) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Protein-sorting complex (Stam2, Hgs, Eps15) protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hgs in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein HGS from the curated Hub Proteins Protein-Protein Interactions dataset.

From NURSA Protein Complexes

proteins in the BL4285 (HGS) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL4284 (HGS) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for HGS from the Pathway Commons Protein-Protein Interactions dataset.

From DGIdb Drug Targets 2026

interacting proteins for the HGS-1025 drug from theDGIdb Drug Targets 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HGS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.