Harmonizome 3.0

HNF1 homeobox A

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

HNF1A antisense RNA 1

Biomarker of colon cancer and stomach cancer. [provided by Alliance of Genome Resources, Mar 2025]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hnf1a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for HNF1A from the Pathway Commons Protein-Protein Interactions dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the HNF1A transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Hnf1a transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HNF1A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From ChEA Transcription Factor Targets 2022

target genes of the HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the HNF1A-26855178-CACO2-HUMAN-COLON-ADENOCARCINOMA transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Hyperinsulinism due to HNF1A deficiency phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6122955-elife-33947-supp2.xlsx-NY8_v_NY15_DE_Bru-seq-HNF1A-regulated_genes_Bru-seq_after_shRNA_in_NY8_or_NY15_cells_-_related_to_Figure_7A_HNF1A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6122955-elife-33947-supp2.xlsx-HNF1A_activated_bound_survival-HNF1A-upregulated_and_-bound_genes_association_between_gene_expression_and_survival_in_TCGA_PAAD_tumors_-_related_to_Figure_7E_HNF1A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6122955-elife-33947-supp2.xlsx-HNF1A_activated_survival-HNF1A-upregulated_genes_association_between_gene_expression_and_survival_in_TCGA_PAAD_tumors_-_related_to_Figure_7-figure_supplement_1A_HNF1A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6122955-elife-33947-supp2.xlsx-HNF1A_repressed_survival-HNF1A-downregulated_genes_association_between_gene_expression_and_survival_in_TCGA_PAAD_tumors_-_related_to_Figure_7-figure_supplement_1B_HNF1A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC12713692-mpa-55-e82-s009.xlsx-HNF1A-_KRT81-_vs_Ctrl-Gene_Name_HNF1A transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.