Harmonizome 3.0

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term itga2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for ITGA2 from the MSigDB Cancer Gene Co-expression Modules dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ITGA2 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the ITGA2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CORUM Protein Complexes

proteins in the ITGA2-ITGB1-CD47 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ITGA2-ITGB1-COL6A3 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ITGA2-ITGB1-CHAD complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ITGA2-ITGB1 complex protein complex from the CORUM Protein Complexes dataset.