Harmonizome 3.0

IL2-inducible T-cell kinase

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term itk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase ITK from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ITK from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase ITK from the curated PhosphoSitePlus Substrates of Kinases dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the ITK gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Kinase Library Tyrosine Kinome Atlas

substrates of the kinase ITK from the Kinase Library Tyrosine Kinome Atlas dataset.

From CORUM Protein Complexes

proteins in the SLP-76-PLC-gamma-1-ITK complex, alpha-TCR stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ITK-SLP-76 complex, anti-TCR stimulated protein complex from the CORUM Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the EPI-1625-1 (ITK) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Itk Deficiency in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.