Harmonizome 3.0

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

From ENCODE Transcription Factor Targets

target genes of the NFATC1 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nfatc1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NFATC1 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the NFATC1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Nfatc1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NFATC1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.