Harmonizome 3.0

nitric oxide synthase 3 (endothelial cell)

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nos3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NOS3 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NOS3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the NOS3-CAV1-NOSTRIN complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the UTM-SGCE-DAG1-CAV1-NOS3 complex protein complex from the CORUM Protein Complexes dataset.

From Reactome Pathways 2024

proteins participating in the Metabolism of nitric oxide: NOS3 activation and regulation pathway from the Reactome Pathways 2024 dataset.