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NR1H3 Genenuclear receptor subfamily 1, group H, member 3 The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
NR1H3-23393188-ATHEROSCLEROTIC-FOAM-HUMAN Gene SetFrom ChEA Transcription Factor Binding Site Profiles genes with transcription factor binding evidence in the NR1H3-23393188-ATHEROSCLEROTIC-FOAM-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset. |
NR1H3-23393188-ATHEROSCLEROTIC-FOAM-HUMAN Gene SetFrom ChEA Transcription Factor Targets 2022 target genes of the NR1H3-23393188-ATHEROSCLEROTIC-FOAM-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. |
NR1H3 Gene SetFrom ChEA Transcription Factor Targets target genes of the NR1H3 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. |
nr1h3 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term nr1h3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
NR1H3 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for NR1H3 from the Pathway Commons Protein-Protein Interactions dataset. |
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Gene Setproteins participating in the NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis pathway from the Reactome Pathways 2024 dataset. |
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis Gene Setproteins participating in the NR1H2 & NR1H3 regulate gene expression linked to lipogenesis pathway from the Reactome Pathways 2024 dataset. |
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Gene Setproteins participating in the NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose pathway from the Reactome Pathways 2024 dataset. |
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Gene Setproteins participating in the NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis pathway from the Reactome Pathways 2024 dataset. |
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Gene Setproteins participating in the NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake pathway from the Reactome Pathways 2024 dataset. |
NR1H2 and NR1H3-mediated signaling Gene Setproteins participating in the NR1H2 and NR1H3-mediated signaling pathway from the Reactome Pathways 2024 dataset. |
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Gene Setproteins participating in the NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux pathway from the Reactome Pathways 2024 dataset. |
Nr1h3 Gene SetFrom JASPAR Predicted Mouse Transcription Factor Targets 2025 target genes of the Nr1h3 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset. |
Nr1h3::Rxra Gene SetFrom JASPAR Predicted Mouse Transcription Factor Targets 2025 target genes of the Nr1h3::Rxra transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset. |
NR1H3 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the NR1H3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |