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NTRK2 Geneneurotrophic tyrosine kinase, receptor, type 2 This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
ntrk2 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term ntrk2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
NTRK2 Gene SetFrom KEA Substrates of Kinases substrates of the kinase NTRK2 from the curated KEA Substrates of Kinases dataset. |
NTRK2 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for NTRK2 from the Pathway Commons Protein-Protein Interactions dataset. |
NTRK2 Gene SetFrom PhosphoSitePlus Substrates of Kinases substrates of the kinase NTRK2 from the curated PhosphoSitePlus Substrates of Kinases dataset. |
NTRK2 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the NTRK2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
Activated NTRK2 signals through CDK5 Gene Setproteins participating in the Activated NTRK2 signals through CDK5 pathway from the Reactome Pathways 2024 dataset. |
Activated NTRK2 signals through FRS2 and FRS3 Gene Setproteins participating in the Activated NTRK2 signals through FRS2 and FRS3 pathway from the Reactome Pathways 2024 dataset. |
Activated NTRK2 signals through FYN Gene Setproteins participating in the Activated NTRK2 signals through FYN pathway from the Reactome Pathways 2024 dataset. |
Activated NTRK2 signals through PI3K Gene Setproteins participating in the Activated NTRK2 signals through PI3K pathway from the Reactome Pathways 2024 dataset. |
Activated NTRK2 signals through PLCG1 Gene Setproteins participating in the Activated NTRK2 signals through PLCG1 pathway from the Reactome Pathways 2024 dataset. |
Activated NTRK2 signals through RAS Gene Setproteins participating in the Activated NTRK2 signals through RAS pathway from the Reactome Pathways 2024 dataset. |
BDNF activates NTRK2 (TRKB) signaling Gene Setproteins participating in the BDNF activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset. |
NTF3 activates NTRK2 (TRKB) signaling Gene Setproteins participating in the NTF3 activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset. |
NTF4 activates NTRK2 (TRKB) signaling Gene Setproteins participating in the NTF4 activates NTRK2 (TRKB) signaling pathway from the Reactome Pathways 2024 dataset. |
NTRK2 activates RAC1 Gene Setproteins participating in the NTRK2 activates RAC1 pathway from the Reactome Pathways 2024 dataset. |
Signaling by NTRK2 (TRKB) Gene Setproteins participating in the Signaling by NTRK2 (TRKB) pathway from the Reactome Pathways 2024 dataset. |