Harmonizome 3.0

polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

From ENCODE Transcription Factor Targets

target genes of the POLR2A transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term polr2a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein POLR2A from the curated Hub Proteins Protein-Protein Interactions dataset.

From NURSA Protein-Protein Interactions

interacting proteins for POLR2A from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for POLR2A from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the POLR2A gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the POLR2A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Actin-ribonucleoprotein complex (POLR2A, GTF2F1, HNRNPU) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRCA1-BARD1-POLR2A complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CPSF6-ITCH-NUDT21-POLR2A complex protein complex from the CORUM Protein Complexes dataset.