Harmonizome 3.0

protein phosphatase 1, catalytic subunit, alpha isozyme

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

From DEPOD Substrates of Phosphatases

substrates of the phosphatase PPP1CA from the curated DEPOD Substrates of Phosphatases dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ppp1ca in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein PPP1CA from the curated Hub Proteins Protein-Protein Interactions dataset.

From KEA Substrates of Kinases

substrates of the kinase PPP1CA from the curated KEA Substrates of Kinases dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for PPP1CA from the MSigDB Cancer Gene Co-expression Modules dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PPP1CA from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the PPP1CA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the PPP1CA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From NURSA Protein Complexes

proteins in the BL3918 (PPP1CA) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.