Harmonizome 3.0

From Sanger Cancer Dependency Map

Protein intensity values acquired using data-independent acquisition mass spectrometry (DIA-MS).

From Cell Maps for AI

Protein localization assemblies constructed from integrating AP-MS biomolecular interaction and IF imaging data

From Gene Expression Omnibus

mRNA expression profiles for cell lines or tissues following kinase perturbation (inhibition, activation, knockdown, knockout, over-expression, mutation)

From LINCS Kinativ

Percent inhibition of kinases by small molecules measured in cell lysates

From LINCS KinomeScan

Kinase inhibitor targets from percent inhibition of kinases by small molecules measured using purified kinases

From Kinase Library

A phosphoproteomics atlas detailing phosphorylation of protein substrates by 303 serine/threonine kinases in the human kinome.

From Kinase Library

A phosphoproteomics atlas detailing phosphorylation of protein substrates by 93 canonical and non-canonical tyrosine kinases in the human kinome.

From Kinase Enrichment Analysis

Protein substrates of kinases from published low-throughput and high-throughput phosphoproteomics studies

From Connectivity Map

mRNA expression profiles for cell lines following chemical perturbation

From Human Proteome Map

Protein expression profiles for tissues and cell types

From LINCS L1000 Connectivity Map

mRNA expression profiles for cell lines following small molecule perturbation

From LINCS L1000 Connectivity Map

Gene association consensus signatures following CRISPR gene knockout

From LINCS L1000 Connectivity Map

Gene association consensus signatures following small molecule perturbation

From Cancer Dependency Map

Dependency scores for cell lines following single gene knockdowns