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RHOH Generas homolog family member H The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013] |
rhoh Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term rhoh in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
RHOH Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for RHOH from the Pathway Commons Protein-Protein Interactions dataset. |
RHOH Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the RHOH gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
RHOH Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the RHOH gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
RHOH GTPase cycle Gene Setproteins participating in the RHOH GTPase cycle pathway from the Reactome Pathways 2024 dataset. |