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SAE1 GeneSUMO1 activating enzyme subunit 1 Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] |
sae1 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term sae1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
SAE1 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for SAE1 from the Pathway Commons Protein-Protein Interactions dataset. |
SAE1 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the SAE1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
SUMO is conjugated to E1 (UBA2:SAE1) Gene Setproteins participating in the SUMO is conjugated to E1 (UBA2:SAE1) pathway from the Reactome Pathways dataset. |
SUMO is conjugated to E1 (UBA2:SAE1) Gene Setproteins participating in the SUMO is conjugated to E1 (UBA2:SAE1) pathway from the Reactome Pathways 2024 dataset. |