Name

SIRT2 Gene

sirtuin 2

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

sirt2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sirt2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SIRT2 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for SIRT2 from the MSigDB Cancer Gene Co-expression Modules dataset.

SIRT2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SIRT2 from the Pathway Commons Protein-Protein Interactions dataset.

SIRT2 Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the SIRT2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

sirt2mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sirt2mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BL3199 (SIRT2) Gene Set

From NURSA Protein Complexes

proteins in the BL3199 (SIRT2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL3196 (SIRT2) Gene Set

From NURSA Protein Complexes

proteins in the BL3196 (SIRT2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.