Harmonizome 3.0

SMAD family member 1

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

SMAD1 antisense RNA 2

SMAD1 antisense RNA 1

From ChEA Transcription Factor Targets

target genes of the SMAD1 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term smad1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein SMAD1 from the curated Hub Proteins Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SMAD1 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SMAD1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the SMAD1-18555785-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From CORUM Protein Complexes

proteins in the SMAD1-P300 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD1-CBP complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ecsit complex (Ecsit2-Smad1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Smad1-Notch1-p300-Pcaf complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ecsit complex (Smad1-Smad4-Ecsit2) protein complex from the CORUM Protein Complexes dataset.

From ChEA Transcription Factor Targets 2022

target genes of the SMAD1-18555785-MESCS-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the SMAD1-26771354-MESC-MOUSE-STEM transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.