Harmonizome 3.0

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]

From DGIdb Drug Targets 2026

interacting proteins for the SMARCA2 DEGRADER PRT7732 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the SELECTIVE ESTROGEN RECEPTOR DEGRADER AZD9496 drug from theDGIdb Drug Targets 2026 dataset.

From CORUM Protein Complexes

proteins in the Smarcb1/Ini1-Smarca2-Mecp2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMARCA2/BRM-BAF57-MECP2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Cebpa-Smarca2 complex protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SWI/SNF complex subunit SMARCA2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From NURSA Protein-Protein Interactions

interacting proteins for SMARCA2 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SMARCA2 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the SMARCA2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the SMARCA2-related BAFopathy phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SMARCA2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.