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SPEN Genespen family transcriptional repressor This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008] |
Spen paralogue/orthologue C-terminal, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Spen paralogue/orthologue C-terminal, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
orthologue Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term orthologue in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
paralogue Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term paralogue in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
Spen-Hivep1 complex Gene Setproteins in the Spen-Hivep1 complex protein complex from the CORUM Protein Complexes dataset. |
BL1730 (SPEN) Gene Setproteins in the BL1730 (SPEN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset. |
BL1733 (SPEN) Gene Setproteins in the BL1733 (SPEN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset. |
BL1731 (SPEN) Gene Setproteins in the BL1731 (SPEN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset. |
BL1732 (SPEN) Gene Setproteins in the BL1732 (SPEN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset. |
SPEN Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for SPEN from the Pathway Commons Protein-Protein Interactions dataset. |
SPEN Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the SPEN gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
metazoa Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term metazoa in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
dermatan sulfate degradation (metazoa) Gene SetFrom HumanCyc Pathways proteins participating in the dermatan sulfate degradation (metazoa) pathway from the HumanCyc Pathways dataset. |
chondroitin sulfate degradation (metazoa) Gene SetFrom HumanCyc Pathways proteins participating in the chondroitin sulfate degradation (metazoa) pathway from the HumanCyc Pathways dataset. |
Ionotropic glutamate receptor, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Ionotropic glutamate receptor, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Epsin-3, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Epsin-3, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Mediator complex, subunit Med8, fungi/metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Mediator complex, subunit Med8, fungi/metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Peptidoglycan recognition protein family domain, metazoa/bacteria Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Peptidoglycan recognition protein family domain, metazoa/bacteria protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
HAUS augmin-like complex subunit 2, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the HAUS augmin-like complex subunit 2, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Transcriptional enhancer factor, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Transcriptional enhancer factor, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Checkpoint protein Rad24, fungi/metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Checkpoint protein Rad24, fungi/metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Anaphase-promoting complex subunit 4, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Anaphase-promoting complex subunit 4, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Mediator complex, subunit Med29, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Mediator complex, subunit Med29, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Mediator complex, subunit Med18, metazoa/fungi Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Mediator complex, subunit Med18, metazoa/fungi protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Pyroglutamyl peptidase I, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Pyroglutamyl peptidase I, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Mediator complex, subunit Med30, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Mediator complex, subunit Med30, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Proteinase inhibitor I2, Kunitz metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Proteinase inhibitor I2, Kunitz metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Origin recognition complex, subunit 6, metazoa/plant Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Origin recognition complex, subunit 6, metazoa/plant protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Alpha-L-fucosidase, metazoa-type Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Alpha-L-fucosidase, metazoa-type protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Homeodomain, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Homeodomain, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Integrator complex subunit 2, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Integrator complex subunit 2, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Protein phosphatase 1 regulatory subunit 3B/C/D, Metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Protein phosphatase 1 regulatory subunit 3B/C/D, Metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
tRNA (uracil-5-)-methyltransferase, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the tRNA (uracil-5-)-methyltransferase, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Glycogen debranching enzyme, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Glycogen debranching enzyme, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Proteinase inhibitor I1, Kazal metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Proteinase inhibitor I1, Kazal metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
HAUS complex subunit 5, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the HAUS complex subunit 5, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Zinc finger, N-recognin, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Zinc finger, N-recognin, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Histone H3-K79 methyltransferase, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Histone H3-K79 methyltransferase, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
ATPase, V0 complex, subunit e1/e2, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the ATPase, V0 complex, subunit e1/e2, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Mediator complex, subunit Med19, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Mediator complex, subunit Med19, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Thymosin beta-4, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Thymosin beta-4, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Mediator complex, subunit Med15, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Mediator complex, subunit Med15, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
HAUS augmin-like complex subunit 4, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the HAUS augmin-like complex subunit 4, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Gem-associated protein 2, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Gem-associated protein 2, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Epsin-2, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Epsin-2, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Mediator complex, subunit Med1, metazoa/fungi Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Mediator complex, subunit Med1, metazoa/fungi protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Mediator complex, subunit Med6, metazoa/plant Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Mediator complex, subunit Med6, metazoa/plant protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
DNA (cytosine-5)-methyltransferase 1, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the DNA (cytosine-5)-methyltransferase 1, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Uncharacterised protein family UPF0368, metazoa/fungi Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Uncharacterised protein family UPF0368, metazoa/fungi protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Peroxisomal membrane protein 11C, metazoa Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Peroxisomal membrane protein 11C, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset. |