Harmonizome 3.0

twist family bHLH transcription factor 2

The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term twist2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for TWIST2 from the Pathway Commons Protein-Protein Interactions dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Twist2 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the TWIST2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.