Harmonizome 3.0

vesicle-associated membrane protein 2 (synaptobrevin 2)

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vamp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for VAMP2 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the VAMP2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX1a, CPLX1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX1a, CPLX1, CPLX3) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX1a, CPLX3, CPLX4) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX11, VAMP2, SNAP23) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (SNAP25, VAMP3, VAMP2, NAPB, STX13) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (STX4, SNAP23, VAMP2) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (Stx4, Vamp2, Snap23) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX1a, STX3, CPLX1, CPLX3, CPLX4) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX13) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SNARE complex (VAMP2, SNAP25, STX1a, CPLX2) protein complex from the CORUM Protein Complexes dataset.