Harmonizome 3.0

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [provided by RefSeq, Jun 2022]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term vhl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein VHL from the curated Hub Proteins Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for VHL from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Phosphosite-Disease Associations

proteins associated with the disease VHL from the curated PhosphoSitePlus Phosphosite-Disease Associations dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the VHL gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the VHL-TCEB1-TCEB2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the VHL-VDU1-TCEB1-TCEB2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the VHL-TBP1-HIF1A complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) protein complex from the CORUM Protein Complexes dataset.

From GAD Gene-Disease Associations

genes associated with the disease von hippel-lindau syndrome (vhl). in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.