Harmonizome 3.0

MAP/microtubule affinity-regulating kinase 4

This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

MAP/microtubule affinity-regulating kinase 1

Enables several functions, including ATP binding activity; magnesium ion binding activity; and phospholipid binding activity. Involved in intracellular signal transduction; negative regulation of epithelial to mesenchymal transition; and protein phosphorylation. Located in cytoplasm; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

MAP/microtubule affinity-regulating kinase 2

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

MAP/microtubule affinity-regulating kinase 3

The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

microtubule cross-linking factor 1-like

regulator of microtubule dynamics 2

Enables microtubule binding activity. Located in Golgi apparatus; cytosol; and spindle. [provided by Alliance of Genome Resources, Mar 2025]

regulator of microtubule dynamics 3

Enables microtubule binding activity. Involved in intracellular calcium ion homeostasis. Located in several cellular components, including intercellular bridge; mitochondrial outer membrane; and spindle. [provided by Alliance of Genome Resources, Mar 2025]

regulator of microtubule dynamics 1

Enables microtubule binding activity. Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore and mitotic spindle organization. Located in mitotic spindle pole and spindle microtubule. [provided by Alliance of Genome Resources, Mar 2025]

hook microtubule-tethering protein 2

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

hook microtubule-tethering protein 3

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

hook microtubule-tethering protein 1

This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Janus kinase and microtubule interacting protein 3

Predicted to enable kinase binding activity and microtubule binding activity. Predicted to be located in Golgi apparatus and membrane. [provided by Alliance of Genome Resources, Mar 2025]

janus kinase and microtubule interacting protein 2

The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

janus kinase and microtubule interacting protein 1

Enables GABA receptor binding activity and RNA binding activity. Involved in cognition. Located in membrane. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Mar 2025]

MAP/microtubule affinity-regulating kinase 2 pseudogene

MAP/microtubule affinity-regulating kinase 1 pseudogene

microtubule crosslinking factor 1

Enables microtubule binding activity. Involved in chromosome segregation. Located in kinetochore; midbody; and spindle. [provided by Alliance of Genome Resources, Mar 2025]

MAP/microtubule affinity-regulating kinase 2 pseudogene 12

MIT, microtubule interacting and transport, domain containing 1

Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

MAP/microtubule affinity-regulating kinase 2 pseudogene 8

MAP/microtubule affinity-regulating kinase 2 pseudogene 9

MAP/microtubule affinity-regulating kinase 2 pseudogene 4

MAP/microtubule affinity-regulating kinase 2 pseudogene 5

MAP/microtubule affinity-regulating kinase 2 pseudogene 6

MAP/microtubule affinity-regulating kinase 2 pseudogene 7

MAP/microtubule affinity-regulating kinase 2 pseudogene 1

MAP/microtubule affinity-regulating kinase 2 pseudogene 2

MAP/microtubule affinity-regulating kinase 2 pseudogene 3

MAP/microtubule affinity-regulating kinase 2 pseudogene

MAP/microtubule affinity-regulating kinase 4 pseudogene

microtubule-actin crosslinking factor 1

This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]

MAP/microtubule affinity-regulating kinase 2 pseudogene

MAP/microtubule affinity-regulating kinase 4 pseudogene

MAP/microtubule affinity-regulating kinase 2 pseudogene 16

MAP/microtubule affinity-regulating kinase 2 pseudogene 17

MAP/microtubule affinity-regulating kinase 2 pseudogene 14

MAP/microtubule affinity-regulating kinase 2 pseudogene 15

MAP/microtubule affinity-regulating kinase 2 pseudogene 13

MAP/microtubule affinity-regulating kinase 2 pseudogene 10

MAP/microtubule affinity-regulating kinase 2 pseudogene 11

microtubule-binding protein-like

MAP/microtubule affinity-regulating kinase 3 pseudogene 1

MAP/microtubule affinity-regulating kinase 3 pseudogene 3

MAP/microtubule affinity-regulating kinase 3 pseudogene 2

MAP/microtubule affinity-regulating kinase 2 pseudogene

MAP/microtubule affinity-regulating kinase 2 pseudogene

piercer of microtubule wall 1

Predicted to be involved in axoneme assembly; establishment of left/right asymmetry; and flagellated sperm motility. Predicted to act upstream of or within DNA damage response; cellular response to UV-C; and regulation of gene expression. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Mar 2025]

piercer of microtubule wall 2

Predicted to be involved in axoneme assembly; determination of left/right symmetry; and flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Mar 2025]

sperm microtubule inner protein 3

ciliary microtubule inner protein 3

Predicted to enable calcium ion binding activity. Predicted to be involved in visual perception. [provided by Alliance of Genome Resources, Mar 2025]

sperm microtubule inner protein 8

Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. [provided by Alliance of Genome Resources, Mar 2025]

ciliary microtubule inner protein 7

ciliary microtubule inner protein 2C

Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Mar 2025]

ciliary microtubule inner protein 4

Predicted to be located in sperm flagellum. [provided by Alliance of Genome Resources, Mar 2025]

ciliary microtubule inner protein 2A

Predicted to be involved in flagellated sperm motility. Located in ciliary basal body. [provided by Alliance of Genome Resources, Mar 2025]

sperm microtubule inner protein 6

This gene encodes a nuclear- or perinuclear-localized protein with no predicted domains or similarity to other known proteins. Expression of this gene is induced during the differentiation of bronchial epithelial cells, and the encoded protein may play a role in ciliogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

ciliary microtubule inner protein 1

Located in cilium. [provided by Alliance of Genome Resources, Mar 2025]

sperm microtubule inner protein 2

sperm microtubule inner protein 9

Predicted to be involved in flagellated sperm motility. Located in cytosol. [provided by Alliance of Genome Resources, Mar 2025]

sperm microtubule inner protein 7

Predicted to be involved in spermatogenesis. [provided by Alliance of Genome Resources, Mar 2025]

sperm microtubule inner protein 5

Predicted to be involved in flagellated sperm motility. Predicted to be located in several cellular components, including cytoskeleton; motile cilium; and nucleus. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. [provided by Alliance of Genome Resources, Mar 2025]

sperm microtubule inner protein 10

Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Predicted to be active in axonemal B tubule inner sheath and sperm flagellum. [provided by Alliance of Genome Resources, Mar 2025]

sperm microtubule inner protein 1

sperm microtubule inner protein 11

Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm; cytoskeleton; and sperm flagellum. Predicted to be active in axonemal A tubule inner sheath. [provided by Alliance of Genome Resources, Mar 2025]

ciliary microtubule inner protein 2B

Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Mar 2025]

sperm microtubule inner protein 4

manchette microtubule inner protein 1

Predicted to be involved in actin filament organization and cell migration. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]