APEX1

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Results for "APEX1": 1 gene, 7 gene sets

Name
APEX1 Gene APEX nuclease (multifunctional DNA repair enzyme) 1 The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.[provided by RefSeq, Dec 2019]
apex1 Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term apex1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
APEX1 Gene Set From MSigDB Cancer Gene Co-expression Modules co-expressed genes for APEX1 from the MSigDB Cancer Gene Co-expression Modules dataset.
APEX1 Gene Set From Pathway Commons Protein-Protein Interactions interacting proteins for APEX1 from the Pathway Commons Protein-Protein Interactions dataset.
APEX1 Gene Set From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the APEX1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
APEX1 Gene Set From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the APEX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Gene Set From Reactome Pathways 2024 proteins participating in the APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway pathway from the Reactome Pathways 2024 dataset.
Displacement of DNA glycosylase by APEX1 Gene Set From Reactome Pathways 2024 proteins participating in the Displacement of DNA glycosylase by APEX1 pathway from the Reactome Pathways 2024 dataset.