Harmonizome 3.0

APH1B gamma secretase subunit

This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term aph1b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for APH1B from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the APH1B gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the APH1B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN) protein complex from the CORUM Protein Complexes dataset.