Harmonizome 3.0

protein kinase D2

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

From NURSA Protein Complexes

proteins in the BL844 (PRKD2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term prkd2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase PRKD2 from the curated KEA Substrates of Kinases dataset.

From NURSA Protein Complexes

proteins in the EPI-1962-1 (PRKD2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL843 (PRKD2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PRKD2 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase PRKD2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase PRKD2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the PRKD2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the PRKD2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.