Harmonizome 3.0

Bloom syndrome, RecQ helicase-like

The Bloom syndrome is an autosomal recessive disorder characterized by growth deficiency, microcephaly and immunodeficiency among others. It is caused by homozygous or compound heterozygous mutation in the gene encoding DNA helicase RecQ protein on chromosome 15q26. This Bloom-associated helicase unwinds a variety of DNA substrates including Holliday junction, and is involved in several pathways contributing to the maintenance of genome stability. Identification of pathogenic Bloom variants is required for heterozygote testing in at-risk families. [provided by RefSeq, May 2020]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term blm in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for BLM from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the BLM gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the BLM gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the BLM-TOP3A complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BLM complex III protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BLM-RAD51L3-XRCC2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RPA-MSH4-BLM complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MSH2/6-BLM-p53-RAD51 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BLM complex II protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BLM-TRF2 complex protein complex from the CORUM Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL892 (BLM) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores

proteins co-occuring with the tissue blm cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue BLM cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.