Harmonizome 3.0

bone morphogenetic protein 2

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bmp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for BMP2 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the BMP2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the BMP2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the CHL2-BMP2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BMP2-BRIA complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CHL2-BMP2-TSG complex protein complex from the CORUM Protein Complexes dataset.

From HuBMAP Azimuth Cell Type Annotations

genes associated with the Human - Motor Cortex - Cluster - LAMP5+ BMP2+ Layer 1 GABAergic neuron cell type from the HuBMAP Azimuth Cell Type Annotations dataset.

From WikiPathways Pathways 2024

proteins participating in the BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation pathway from the WikiPathways Pathways 2024 dataset.

From HuBMAP ASCT+B Annotations

biomarker genes for the Brain_CT2_Inh L1 LAMP5 BMP2 cell type from the HuBMAP ASCT+B dataset.

From HuBMAP ASCT+B Augmented with RNA-seq Coexpression

biomarker genes for the Brain_CT2_Inh L1 LAMP5 BMP2 cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.