Harmonizome 3.0

cyclin D1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the CCND1-20090754-RETINA-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets 2022

target genes of the CCND1-20090754-RETINA-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From NURSA Protein Complexes

proteins in the a-CCND1 (Ab3) (CCND1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From ChEA Transcription Factor Targets

target genes of the CCND1 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From CORUM Protein Complexes

proteins in the CDK4-CCND1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CCND1-CDK6 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CCND1-CDK4 complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccnd1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From NURSA Protein Complexes

proteins in the SC-8396 (CCND1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CCND1 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CCND1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the CCND1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.