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CCR1 Genechemokine (C-C motif) receptor 1 This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008] |
ccr1 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term ccr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
CCR1 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for CCR1 from the Pathway Commons Protein-Protein Interactions dataset. |
CCR1 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the CCR1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
ccr1 chemokine receptor binding Gene SetFrom GO Molecular Function Annotations 2015 genes performing the ccr1 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset. |
CCR1 chemokine receptor binding Gene SetFrom GO Molecular Function Annotations 2023 genes performing the CCR1 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset. |
CCR1 chemokine receptor binding Gene SetFrom GO Molecular Function Annotations 2025 genes performing the CCR1 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset. |