Harmonizome 3.0

chemokine (C-C motif) receptor 2

The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]

From DGIdb Drug Targets 2026

interacting proteins for the CCR2-RA-[R] drug from theDGIdb Drug Targets 2026 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccr2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Molecular Function Annotations 2015

genes performing the ccr2 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CCR2 from the Pathway Commons Protein-Protein Interactions dataset.

From GO Molecular Function Annotations 2023

genes performing the CCR2 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CCR2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From GO Molecular Function Annotations 2025

genes performing the CCR2 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.