Harmonizome 3.0

chemokine (C-X-C motif) receptor 3

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cxcr3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CXCR3 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CXCR3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From GO Molecular Function Annotations 2015

genes performing the cxcr3 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From PID Pathways

proteins participating in the CXCR3-mediated signaling events pathway from the PID Pathways dataset.

From GO Molecular Function Annotations 2023

genes performing the CXCR3 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2025

genes performing the CXCR3 chemokine receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.