Harmonizome 3.0

drosha, ribonuclease type III

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the DROSHA-22980978-HELA-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets 2022

target genes of the DROSHA-22980978-HELA-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets

target genes of the DROSHA transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From CORUM Protein Complexes

proteins in the Large Drosha complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Drosha complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term drosha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for DROSHA from the Pathway Commons Protein-Protein Interactions dataset.

From WikiPathways Pathways 2024

proteins participating in the DDX1 as a regulatory component of the Drosha microprocessor pathway from the WikiPathways Pathways 2024 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the DROSHA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.