Harmonizome 3.0

EPH receptor A2

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term epha2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase EPHA2 from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for EPHA2 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase EPHA2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From Kinase Library Tyrosine Kinome Atlas

substrates of the kinase EPHA2 from the Kinase Library Tyrosine Kinome Atlas dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the EPHA2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the TIAM1-EFNB1-EPHA2 complex protein complex from the CORUM Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL8125 (EPHA2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From PID Pathways

proteins participating in the EPHA2 forward signaling pathway from the PID Pathways dataset.