Harmonizome 3.0

TLR adaptor interacting with endolysosomal SLC15A4

Involved in positive regulation of toll-like receptor 7 signaling pathway; positive regulation of toll-like receptor 8 signaling pathway; and regulation of lysosomal lumen pH. Located in endolysosome membrane and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

endogenous retrovirus group K member 8 Gag polyprotein-like

endogenous retrovirus group W, member 28

endogenous retrovirus group V, member 1

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. The gene's envelope protein is expressed in the human placenta but is truncated at its C-terminus. [provided by RefSeq, Oct 2015]

endogenous retrovirus group V, member 2

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. This envelope glycoprotein gene appears to have been selectively preserved. The gene's protein product is expressed in the placenta and acts as a syncytin in Old World monkeys, but has lost the fusogenic activity in humans and other primate lineages. [provided by RefSeq, Jun 2015]

endogenous retrovirus group H, member 2

endogenous retrovirus group H, member 3

endogenous retrovirus group H, member 1

endogenous retrovirus group H, member 6

endogenous retrovirus group H, member 4

endogenous retrovirus group H, member 5

endogenous retrovirus group E, member 3

endogenous retrovirus group E, member 1

endogenous retrovirus group E, member 4

endogenous retrovirus group S71 member 1 Env polyprotein

endogenous retrovirus group K, member 19

endogenous retrovirus group K, member 18

endogenous retrovirus group K, member 14

endogenous retrovirus group K, member 17

endogenous retrovirus group K, member 11

endogenous retrovirus group K, member 13

endogenous retrovirus group K, member 12

endogenous retrovirus group MER61, member 1

apelin receptor early endogenous ligand

This gene encodes a peptide hormone that binds to the Apelin receptor. The encoded protein is required for heart development in zebrafish and has been shown to maintain self-renewal of human embryonic stem cells through activation of the PI3K/AKT pathway. Experiments in human and mouse cell lines point to additional roles for the encoded protein in angiogenesis and regulation of vascular tone. [provided by RefSeq, Jul 2016]

endogenous retrovirus group I, member 1

endogenous retrovirus group K member 19 Pol protein

endogenous Bornavirus-like nucleoprotein 1

endogenous Bornavirus-like nucleoprotein 2

endogenous retrovirus group 18, member 1

endogenous retrovirus group K member 11 Pol protein

endogenous retrovirus group K member 25 Pol protein-like

endogenous retrovirus group PABLB, member 1

endogenous retrovirus group 9, member 1

endogenous Bornavirus-like nucleoprotein 3

endogenous retrovirus group 3, member 1 pseudogene

endogenous retrovirus group 3, member 1 pseudogene

simian sarcoma-associated virus 1/gibbon ape leukemia virus-related endogenous retroviral element 1

endogenous retrovirus group S71, member 1

endogenous retrovirus group H, member 7

endogenous retrovirus group K, member 20

endogenous retrovirus group K, member 21

endogenous retrovirus group K, member 22

endogenous retrovirus group K, member 23

endogenous retrovirus group K, member 24

endogenous retrovirus group K, member 26

endogenous retrovirus group E, member 2

endogenous retrovirus group V member 2 Env polyprotein-like

endogenous retrovirus group K member 5 Gag polyprotein

endogenous retrovirus group FC1, member 1

endogenous retrovirus group K, member 9

endogenous retrovirus group K, member 8

endogenous retrovirus group K, member 1

endogenous retrovirus group K, member 3

endogenous retrovirus group K, member 5

Predicted to enable nucleic acid binding activity; structural molecule activity; and zinc ion binding activity. Predicted to be involved in viral translational frameshifting. Predicted to be located in nucleus and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

endogenous retrovirus group K, member 4

endogenous retrovirus group K, member 7

Predicted to enable RNA stem-loop binding activity. Predicted to be involved in DNA metabolic process; proteolysis; and viral translational frameshifting. Predicted to be located in nucleus and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

endogenous retrovirus group K, member 6

Enables RNA stem-loop binding activity and protein homodimerization activity. Involved in mRNA export from nucleus; positive regulation of gene expression; and protein homooligomerization. Located in cytoplasm and nucleolus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Mar 2025]

endogenous retrovirus group FH21, member 1

endogenous retrovirus group K3, member 3

endogenous retrovirus group K3, member 2

endogenous retrovirus group K3, member 1

endogenous retrovirus group K3, member 6

endogenous retrovirus group K3, member 8

endogenous retrovirus group K, member 15

endogenous retrovirus group K, member 16

endogenous retrovirus group K13, member 1

Predicted to enable structural molecule activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

endogenous retrovirus group K11, member 1

endogenous retrovirus group 3, member 1

This gene contains sequence derived from endogenous retrovirus, and is therefore similar to multiple other loci in the genome. Transcripts at this locus encode a conserved protein with a predicted signal peptide and similarity to the Env polyprotein. This protein is overexpressed in colorectal and other cancers. [provided by RefSeq, Jan 2017]

endogenous retrovirus group 3, member 2

endogenous retrovirus group S71, member 2

endogenous retrovirus group K member 7 Env polyprotein-like

endogenous retrovirus group K, member 2

endogenous retrovirus group K member 25 Env polyprotein-like

endogenous retrovirus group K3, member 4

endogenous retrovirus group MER34, member 1

Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

endogenous retrovirus group FRD, member 1

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]

endogenous retrovirus group FRD, member 2

endogenous retrovirus group FRD, member 3

endogenous retrovirus group 48, member 1

Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has placenta specific expression. The protein encoded has the characteristics of a retroviral envelope protein but is truncated and lacks the transmembrane domain. The protein inhibits cell fusion by competing with syncytin-1 for binding to a cell receptor. [provided by RefSeq, May 2015]

endogenous retrovirus group FC1 Env polyprotein

endogenous retrovirus group K, member 10

HTLV-1 related endogenous sequence 2

HTLV-1 related endogenous sequence

endogenous retrovirus group K, member 25

endogenous retrovirus group K3, member 7

endogenous retrovirus group K3, member 5

endogenous retrovirus group K member 8 Pol protein-like

endogenous retrovirus group W, member 4

endogenous retrovirus group W, member 5

endogenous retrovirus group W, member 6

endogenous retrovirus group W, member 1

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

endogenous retrovirus group W, member 3

endogenous retrovirus group W, member 2

endogenous retrovirus group FC1 Env polyprotein

cytoplasmic endogenous regulator of oxidative phosphorylation 1

competing endogenous lncRNA 1 for miR-4707-5p and miR-4767

endogenous Bornavirus like nucleoprotein 3, pseudogene

endogenous retrovirus group K member 18 Env polyprotein

melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489

endogenous retrovirus group K member 7 Env polyprotein-like